Wil Myers hit two solo homers and a double and Tommy Pham opened the game with a home run Friday night as the San Diego Padres defeated the visiting Cincinnati Reds 8-2.

The win was the Padres' second straight to open the series after losing 13 of 17 before that.

Padres' right-handed starter Chris Paddack (4-5) picked up the win, holding the Reds to two runs on six hits and a walk in five innings while equaling a career-high with 11 strikeouts. Four relievers allowed only a walk and a hit batter over the final four innings.

Cincinnati right-hander Tony Santillan sustained his first loss in his second major league start, giving up single runs in each of the three innings he worked. He gave up four hits and a walk with three strikeouts.

Pham hit Santillan's second pitch of the game into the seats in right center to give the Padres a lead they never relinquished.

Myers, who had been in a 6-for-36 slump and hadn't homered in June, made it 2-0 leading off the second with a low line drive off Santillan just inside the left-field foul pole. His second homer greeted reliever Ashton Goudeau in the fourth.

Down 2-0, the Reds halved the deficit in the top of the third. Kyle Farmer opened the inning with a single, was bunted to second by Santillan, and scored on Jesse Winker's two-out single.

The Padres got that run back in their half of the third. Fernando Tatis Jr. led off with a double down the line in left, moved to third on a grounder to the right side and scored on Manny Machado's sacrifice fly to center.

The Reds crept back to within a run in the top of the fourth. Joey Votto drew a one-out walk from Paddack, advanced to second on a single by Eugenio Suarez, stole third and scored on Farmer's single.

But the Padres scored twice against Goudeau in their half of the inning. After Myers' homer, Jake Cronenworth hit a double, and scored on a single by Tatis.

The Padres' sixth run came in the seventh against Sean Doolittle. Machado opened with a single, moved to second on a ground out and scored on Cronenworth's second double.

Trent Grisham drove home the final two runs with a double off Ryan Hendrix in the eighth.